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| Interactions: | Carbamazepine
Adverse Effect: Increased risperidone clearance Clinical Management: Monitor therapeutic efficacy of risperidone following the addition of carbamazepine; higher risperidone doses may be needed.
Clozapine
Adverse Effect: Decreased risperidone clearance Clinical Management: Monitor patients for increased adverse effects of risperidone when these drugs are given concurrently.
Levodopa
Adverse Effect: loss of levodopa efficacy .Clinical Management: Concurrent use of risperidone in patients with parkinsonism should be avoided. If concurrent use cannot be avoided, monitor the patient for signs of increasing extrapyramidal effects. .
Lithium
Adverse Effect: weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage Clinical Management: Monitor patients closely for any signs of toxicity or extrapyramidal symptoms, especially if high doses of antipsychotic drugs and lithium are used.
Tramadol
Adverse Effect: an increased risk of seizures Clinical Management: Caution should be used if tramadol is to be administered to patients receiving neuroleptic therapy. If possible, avoid this combination |
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